abstract：:Regrowth of peripheral spiral ganglion neuron (SGN) fibers is a primary objective in efforts to improve cochlear implant outcomes and to potentially reinnervate regenerated hair cells. Cyclic adenosine monophosphate (cAMP) regulates neurite growth and guidance via activation of protein kinase A (PKA) and Exchange Prot...

journal_title：Hearing research

authors： Xu N,Engbers J,Khaja S,Xu L,Clark JJ,Hansen MR

更新日期：2012-01-01 00:00:00

abstract：:Inbred strain variants of the Cdh23 gene have been shown to influence the onset and progression of age-related hearing loss (AHL) in mice. In linkage backcrosses, the recessive Cdh23 allele (ahl) of the C57BL/6J strain, when homozygous, confers increased susceptibility to AHL, while the dominant allele (Ahl+) of the C...

journal_title：Hearing research

authors： Kane KL,Longo-Guess CM,Gagnon LH,Ding D,Salvi RJ,Johnson KR

更新日期：2012-01-01 00:00:00

abstract：:Sharp spatial selectivity is critical to auditory performance, particularly in pitch-related tasks. Most contemporary cochlear implants have employed monopolar stimulation that produces broad electric fields, which presumably contribute to poor pitch and pitch-related performance by implant users. Bipolar or tripolar ...

journal_title：Hearing research

authors： Zhu Z,Tang Q,Zeng FG,Guan T,Ye D

更新日期：2012-01-01 00:00:00

abstract：:When hearing thresholds are measured with high-frequency resolution there is a pseudo-periodic variation in thresholds across frequency of up to 15-20dB. This variation is called threshold fine structure (previously referred to as threshold microstructure). Consequently, estimates of auditory status based on threshold...

journal_title：Hearing research

authors： Lee J,Long G

更新日期：2012-01-01 00:00:00

abstract：:A method for long term culture of utricular macula explants is demonstrated to be stable and reproducible over a period of 28 days in vitro (DIV). This culture system for four-day-old rat utricular maculae is potentially suitable for studies of hair cell loss, repair and regeneration processes as they occur in post-na...

journal_title：Hearing research

authors： Werner M,Van De Water TR,Andersson T,Arnoldsson G,Berggren D

更新日期：2012-01-01 00:00:00

abstract：:The human auditory brainstem is known to be exquisitely sensitive to fine-grained spectro-temporal differences between speech sound contrasts, and the ability of the brainstem to discriminate between these contrasts is important for speech perception. Recent work has described a novel method for translating brainstem ...

journal_title：Hearing research

authors： Warrier CM,Abrams DA,Nicol TG,Kraus N

更新日期：2011-12-01 00:00:00

abstract：:The membrane glycoprotein CTL2/SLC44A2 is expressed by supporting cells in the inner ear and has been identified as a target of antibodies that may induce auto-immune hearing loss. To determine if CTL2/SLC44A2 also has roles in inner ear development and to distinguish between isoform-specific roles, we assessed age-re...

journal_title：Hearing research

authors： Beyer LA,Galano MM,Nair TS,Kommareddi PK,Sha SH,Raphael Y,Carey TE

更新日期：2011-12-01 00:00:00

abstract：:It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. Although neural stimulation can be achieved without direct contact of the radiation source and the tissue, the presence of fluids or bone between the target structure and the radiation source may lead to absorption or ...

journal_title：Hearing research

authors： Moreno LE,Rajguru SM,Matic AI,Yerram N,Robinson AM,Hwang M,Stock S,Richter CP

更新日期：2011-12-01 00:00:00

abstract：:The purpose of this study was to evaluate whether there were significant differences in audibility of American English vowels in noise produced by non-native and native speakers. Detection thresholds for 12 English vowels with equalized durations of 170 ms produced by 10 English-, Chinese- and Korean-native speakers w...

journal_title：Hearing research

authors： Liu C,Jin SH

更新日期：2011-12-01 00:00:00

abstract：:Ototoxicity is a dose-limiting side effect of chemotherapeutic treatment with cisplatin. In a series of experiments on neonatal rat cochlear organotypic cultures, the extent of damage induced by a broad range of cisplatin treatment concentrations was examined. Paradoxically, it was found that hair cell loss was greate...

journal_title：Hearing research

authors： Ding D,He J,Allman BL,Yu D,Jiang H,Seigel GM,Salvi RJ

更新日期：2011-12-01 00:00:00

abstract：:This chapter reviews evidence for functional connections of the somatosensory and auditory systems at the very lowest levels of the nervous system. Neural inputs from the dosal root and trigeminal ganglia, as well as their brain stem nuclei, cuneate, gracillis and trigeminal, terminate in the cochlear nuclei. Terminat...

journal_title：Hearing research

authors： Shore SE

更新日期：2011-11-01 00:00:00

abstract：:Recently it was shown that distortion product otoacoustic emissions (DPOAEs) can be measured as vibration of the human tympanic membrane in vivo, and proposed to use these vibration DPOAEs to support a differential diagnosis of middle-ear and cochlear pathologies. Here, we investigate how the reverse transfer function...

journal_title：Hearing research

authors： Dalhoff E,Turcanu D,Gummer AW

更新日期：2011-10-01 00:00:00

abstract：:Noninvasive auditory brainstem responses (ABRs) are commonly used to assess cochlear pathology in both clinical and research environments. In the current study, we evaluated the relationship between ABR characteristics and more direct measures of cochlear function. We recorded ABRs and auditory nerve (AN) single-unit ...

journal_title：Hearing research

authors： Henry KS,Kale S,Scheidt RE,Heinz MG

更新日期：2011-10-01 00:00:00

abstract：:This paper discusses how ion transport proteins in the hair cells of the mammalian cochlea work to produce a sensitive but stable hearing organ. The transport proteins in the inner and outer hair cells are summarized (including their current voltage characteristics), and the roles of these proteins in determining intr...

journal_title：Hearing research

authors： Patuzzi R

更新日期：2011-10-01 00:00:00

abstract：:Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea receives cholinergic innervation from the superior olivary complex. Muc...

journal_title：Hearing research

authors： Schofield BR,Motts SD,Mellott JG

更新日期：2011-09-01 00:00:00

abstract：:The role of glycine and GABA as inhibitory neurotransmitters in the adult vertebrate nervous system has been well characterized in a variety of model systems, including the auditory, which is particularly well suited for analyzing inhibitory neurotransmission. However, a full understanding of glycinergic and GABAergic...

journal_title：Hearing research

authors： Friauf E,Rust MB,Schulenborg T,Hirtz JJ

更新日期：2011-09-01 00:00:00

abstract：:The auditory system can encode interaural delays in highpass-filtered complex sounds by phase locking to their slowly modulating envelopes. Spectrotemporal analysis of interaurally time-delayed highpass waveforms reveals the presence of a concomitant interaural level cue. The current study systematically investigated ...

journal_title：Hearing research

authors： Hsieh IH,Petrosyan A,Gonçalves ÓF,Hickok G,Saberi K

更新日期：2011-07-01 00:00:00

abstract：:This paper reviews some of what is known about ion transport through the cells of the mammalian stria vascularis, and discusses how the endolymph and endocochlear potential in scala media are produced by the stria's main cell types. It discusses the role of each cells' ion transport proteins from an engineering perspe...

journal_title：Hearing research

authors： Patuzzi R

更新日期：2011-07-01 00:00:00

abstract：:In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms. We argue that this classification is only vaguely and variously defined in the literature, and that these terms often have unclear and different meaning to different i...

journal_title：Hearing research

authors： Popper AN,Fay RR

更新日期：2011-03-01 00:00:00

abstract：:The hair cells of the vertebrate inner ear posses active mechanical processes to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism...

journal_title：Hearing research

authors： Elgoyhen AB,Franchini LF

更新日期：2011-03-01 00:00:00

abstract：:The basilar papilla length increases systematically with body mass for 41 species from more than 10 avian orders and this relation does not differ between phylogenetic groups. Audiograms of 25 non-strigiform and 12 owl species, normalized relative to best frequency and best threshold, were used to compare audiogram sh...

journal_title：Hearing research

authors： Gleich O,Langemann U

更新日期：2011-03-01 00:00:00

abstract：:Low-frequency temporal information present in speech is critical for normal perception, however the neural mechanism underlying the differentiation of slow rates in acoustic signals is not known. Data from the rat trigeminal system suggest that the paralemniscal pathway may be specifically tuned to code low-frequency ...

journal_title：Hearing research

authors： Abrams DA,Nicol T,Zecker S,Kraus N

更新日期：2011-02-01 00:00:00

abstract：:Several studies have shown that treatment with various neurotrophins protects spiral ganglion cells (SGCs) from degeneration in hair-cell deprived cochleas. In most of these studies the neurotrophins are delivered by means of intracochlear delivery methods. Recently, other application methods that might be more suited...

journal_title：Hearing research

authors： Havenith S,Versnel H,Agterberg MJ,de Groot JC,Sedee RJ,Grolman W,Klis SF

更新日期：2011-02-01 00:00:00

abstract：:There are three main cues to sound location: the interaural differences in time (ITD) and level (ILD) as well as the monaural spectral shape cues. These cues are generated by the spatial- and frequency-dependent filtering of propagating sound waves by the head and external ears. Although the chinchilla has been used f...

journal_title：Hearing research

authors： Koka K,Jones HG,Thornton JL,Lupo JE,Tollin DJ

更新日期：2011-02-01 00:00:00

abstract：:The human auditory system is comprised of specialized but interacting anatomic and functional pathways encoding object, spatial, and temporal information. We review how learning-induced plasticity manifests along these pathways and to what extent there are common mechanisms subserving such plasticity. A first series o...

journal_title：Hearing research

authors： Spierer L,De Lucia M,Bernasconi F,Grivel J,Bourquin NM,Clarke S,Murray MM

更新日期：2011-01-01 00:00:00

abstract：:We review event-related slow firing changes in the auditory cortex and related brain structures. Two types of changes can be distinguished, namely increases and decreases of firing, lasting in the order of seconds. Triggering events can be auditory stimuli, reinforcers, and behavioral responses. Slow firing changes te...

journal_title：Hearing research

authors： Brosch M,Selezneva E,Scheich H

更新日期：2011-01-01 00:00:00

abstract：:It is widely appreciated that the key predictor of the pitch of a sound is its periodicity. Neural structures which support pitch perception must therefore be able to reflect the repetition rate of a sound, but this alone is not sufficient. Since pitch is a psychoacoustic property, a putative cortical code for pitch m...

journal_title：Hearing research

authors： Walker KM,Bizley JK,King AJ,Schnupp JW

更新日期：2011-01-01 00:00:00

abstract：:Proteomic analysis of cadaveric formalin-fixed, celloidin-embedded (FFCE) temporal bone tissue has the potential to provide new insights into inner ear disorders. We have developed a liquid chromatography-mass spectrometry (LC-MS) method for tissue sections embedded with celloidin. Q-TOF (Quadrupole-time of flight mas...

journal_title：Hearing research

authors： Aarnisalo AA,Green KM,O'Malley J,Makary C,Adams J,Merchant SN,Evans JE

更新日期：2010-12-01 00:00:00

abstract：:Several studies have demonstrated that treatment with intracochlear chronic electrical stimulation (CES) protects spiral ganglion cells (SGCs) from degeneration in deafened animals. Other studies could not confirm this effect of CES. The present study examined whether CES in a mode as presented in cochlear implant use...

journal_title：Hearing research

authors： Agterberg MJ,Versnel H,de Groot JC,van den Broek M,Klis SF

更新日期：2010-10-01 00:00:00

abstract：:Fluorescent tags and fluorophore-conjugated molecular probes have been extensively employed in histological studies to demonstrate nanoparticle distribution in inner ear cell populations. However, autofluorescence that exists in the rodent cochleae disturbs visualization of the fluorescent tags and fluorophore labelin...

journal_title：Hearing research

authors： Zhang Y,Zhang W,Johnston AH,Newman TA,Pyykkö I,Zou J

更新日期：2010-10-01 00:00:00

abstract：:Auditory-nerve fibers demonstrate dynamic response properties in that they adapt to rapid changes in sound level, both at the onset and offset of a sound. These dynamic response properties affect temporal coding of stimulus modulations that are perceptually relevant for many sounds such as speech and music. Temporal d...

journal_title：Hearing research

authors： Scheidt RE,Kale S,Heinz MG

更新日期：2010-10-01 00:00:00

abstract：:Otoconia are biomineral particles of microscopic size essential for perception of gravity and maintenance of balance. Millions of older Americans are affected in their mobility, quality of life and in their health by progressive demineralization of otoconia. Currently, no effective means to prevent or counteract this ...

journal_title：Hearing research

authors： Lu W,Zhou D,Freeman JJ,Thalmann I,Ornitz DM,Thalmann R

更新日期：2010-09-01 00:00:00

abstract：:The purpose of this study is to investigate whether repeated noise exposure aggravates the level of permanent noise-induced hearing loss (NIHL) in diabetic rats and whether N-acetylcysteine (NAC), a precursor of glutathione, attenuates the level of noise-induced permanent hearing loss in diabetic rats. Fifty male Wist...

journal_title：Hearing research

authors： Wu HP,Hsu CJ,Cheng TJ,Guo YL

更新日期：2010-08-01 00:00:00

abstract：:Cave fish have rarely been investigated with regard to their inner ear morphology, hearing abilities, and acoustic communication. Based on a previous study that revealed morphological differences in the saccular otolith between a cave and two surface populations of Poecilia mexicana, we checked for additional differen...

journal_title：Hearing research

authors： Schulz-Mirbach T,Ladich F,Riesch R,Plath M

更新日期：2010-08-01 00:00:00

abstract：:Harmonic complex tones are a particularly important class of sounds found in both speech and music. Although these sounds contain multiple frequency components, they are usually perceived as a coherent whole, with a pitch corresponding to the fundamental frequency (F0). However, when two or more harmonic sounds occur ...

journal_title：Hearing research

authors： Micheyl C,Oxenham AJ

更新日期：2010-07-01 00:00:00

abstract：:Application of dexamethasone to the round window has been shown to ameliorate high frequency hearing loss resulting from the trauma of cochlear implantation in experimental animals, but elucidation of the factors influencing protection of the high frequencies has been confounded by the local trauma from electrode arra...

journal_title：Hearing research

authors： Eastwood H,Chang A,Kel G,Sly D,Richardson R,O'Leary SJ

更新日期：2010-06-14 00:00:00

abstract：:Older adults, even with clinically normal hearing sensitivity, have auditory perceptual deficits relative to their younger counterparts. This difficulty may in part, be related to a decline in the neural representation of frequency. The purpose of this study was to examine the effect of age on behavioral and physiolog...

journal_title：Hearing research

authors： Clinard CG,Tremblay KL,Krishnan AR

更新日期：2010-06-01 00:00:00

abstract：:For the purpose of creating a finite element model of the middle ear, the ossicles can be modelled as rigid bodies or as linear elastic materials. The general elasticity parameters used are usually measured on larger bones like the femur. In order to obtain a highly realistic model, the actual elastic modulus (Young's...

journal_title：Hearing research

authors： Soons JA,Aernouts J,Dirckx JJ

更新日期：2010-05-01 00:00:00

abstract：:When using bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends on the impedance match between the driver and the load (human mastoid or otherwise) to which the driver will be applied. Current clinical calibration methods are incapable of quantifying this impedance m...

journal_title：Hearing research

authors： Weece R,Allen J

更新日期：2010-05-01 00:00:00

abstract：:In the surgical treatment of otosclerosis, the coupling between the stapes prosthesis and the long process of the incus is critical. After surgery, connective tissue and mucosa may grow over the coupling area and thereby influence the sound transmission properties of the incus-prosthesis interface. It was the hypothes...

journal_title：Hearing research

authors： Sim JH,Chatzimichalis M,Huber AM

更新日期：2010-05-01 00:00:00